Angiogenic Activity of the Peritoneal Mesothelium: Implications for Peritoneal Dialysis
نویسندگان
چکیده
منابع مشابه
مقایسه سلولهای مزانشیمی مغز استخوان و سلولهای مزوتلیومی مایع سروزی ازنظر میزان بیان مولکولهای کمپلکس سازگاری نسجی اصلی (MHC)
Abstract Background: Mesothelium is composed of a single layer of mesothelial cells attached to a thin basement membrane supported by subserosal connective tissue it plays an important role in homeostasis, wound healing, fluid transport and inflammation. The introduction of peritoneal dialysis (PD) as a modality of renal replacement therapy has provoked much interest in the biology of perito...
متن کاملThe biology of the mesothelium during peritoneal dialysis.
Substantial derangements of mesothelial biology are observed during experimental simulations of dialysis conditions, inferred from the content of human dialysis effluent and visualized by microscopy of human mesothelial biopsies. Can osmotically active solutions be made biocompatible with the osmoregulatory system of the mesothelium? Can the contributions of the mesothelium to host defenses aga...
متن کاملdialysate contains unphysiological levels of glucose as the osmotic agent. This constant exposure to hyperosmolar and low pH dialysis solution, with high glucose concentration causes additional injury to the peritoneal mesothelium, already damaged by the uremic internal millieu
Investigating peritoneal membrane alterations caused by peritoneal dialysis fluid during peritoneal dialysis in humans is still intriguing. That is why the study was aimed to provide rabbit peritoneal tissue samples suitable for histological analyses using a modified nonuremic infusion model of peritoneal dialysis on rabbit. A double-lumen central venous catheter, surgically placed in the perit...
متن کاملThe mesothelium under the siege of dialysis solutions: old glucose, new glucose, and glucose-free osmotic agents.
Use of one bag of glucose peritoneal dialysis fluid (PDF) results in the development of a dose-related senescent mesothelial cell phenotype not linked to acidic pH or the presence of lactate buffer. This complication derives mostly from oxidative stress induced both by glucose itself and by glucose degradation products (GDPs). New glucose formulations are offered in dual- or three-chambered bag...
متن کاملCorrelational studies on insulin resistance and leptin gene polymorphisms in peritoneal dialysis patients
Objective(s):The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. Materials and Methods: From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high HOMR-IR, and low HOMR-IR). Two PCR products of LEP were sequenced and aligne...
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تاریخ انتشار 2017